Evaluation Of Immunomodulatory Activity Of Meloxicam In Mice. (Record no. 3364)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02249nam a2200181Ia 4500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20151006141425.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 150525s2013 xx 000 0 und d |
| 041 ## - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 1656,T |
| 100 ## - MAIN ENTRY--AUTHOR NAME | |
| Personal name | Ghulam Fatima |
| 110 ## - MAIN ENTRY--CORPORATE NAME | |
| Location of meeting | Dr. Aqeel Javeed |
| 245 ## - TITLE STATEMENT | |
| Title | Evaluation Of Immunomodulatory Activity Of Meloxicam In Mice. |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) | |
| Year of publication | 2013 |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | In the present study, the immunomodulatory activity of meloxicam was evaluated. For the evaluation of effect of meloxicam on cellular immunity the delayed type hypersensitivity assay (DTH) and cyclophosphamide induced neutropenia assay were performed while for humoral immunity haemagglutination assay and mice lethality test was performed. In each assay 15 mice were used, all mice were divided into 3 groups, each group was consist of 5 mice. Two groups were treated with two different doses of meloxicam (5mg/kg and 10 mg/kg) and the one group (control group) was only being administered with dimethylsulphoxide (DMSO) intraperitoneally. In DTH assay, 5mg/kg and 10mg/kg meloxicam treated groups of mice showed a significant reduction in skin thickness ( P<0.05) as compared to control group at 24hours, 48 hours and 72 hours after the challenging dose of dinitrochlorobenzene (DNCB). In cyclophosphamide induced neutropenia assay meloxicam at 10mg/kg showed a significant percentage of reduction in total leukocytes (TLC) and two types of differential leukocytes (DLC i.e lymphocytes, and neutrophils except monocytes). This significant reduction was less in 5mg/kg meloxicam treated group which in turn was less than the control group. In addition, it was observed a dose dependent reduction response in haemagglutination (HA) titre. The order of reduction in HA titre was 10mg/kg meloxicam treated group > 5mg/kg meloxicam treated group > the control group. The mortality ratio of mice in the control group, 5mg/kg meloxicam and 10 mg/kg meloxicam treated groups was 20%, 80% and 100% respectively. All the results of present study suggest that meloxicam has suppressive effect on cellular as well as on humoral component of immune system. |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical Term | Department of Pharmaoclogy & Toxicology |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Prof. Dr. Muhammad Ashraf |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | Thesis |
| Damaged status | Collection code | Permanent Location | Current Location | Shelving location | Date acquired | Full call number | Accession Number | Koha item type |
|---|---|---|---|---|---|---|---|---|
| Veterinary Science | UVAS Library | UVAS Library | Thesis Section | 2015-05-29 | 1656,T | 1656,T | Thesis |