Preparation & Evaluation Of Combined Pre & Fmd Vaccines For Small Ruminants (Record no. 3406)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02959nam a2200181Ia 4500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20151006142835.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 150525s2013 xx 000 0 und d |
| 041 ## - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 1698,T |
| 100 ## - MAIN ENTRY--AUTHOR NAME | |
| Personal name | Zanira Shakoor |
| 110 ## - MAIN ENTRY--CORPORATE NAME | |
| Location of meeting | Dr. Jawad Nazir |
| 245 ## - TITLE STATEMENT | |
| Title | Preparation & Evaluation Of Combined Pre & Fmd Vaccines For Small Ruminants |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) | |
| Year of publication | 2013 |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | PPR is an acute, febrile and contagious viral disease of small ruminants caused by Morbillivirus. Similarly, FMD is another highly contagious viral disease of cloven hoofed animals that affects more than 33 species of domestic and wild animals. Although disease severity is relatively higher in large ruminants but small ruminants might also play an important role in the epidemiology and transmission of FMD. Mass vaccination is the most effective mean to control viral diseases like PPR and FMD in small ruminants. The present study was designed to evaluate the immune response of goats to various monovalent and bivalent as well as adjuvant and non adjuvant PPRV and FMD "O" virus vaccines. A total of nine groups of animals each comprising 5, were inoculated with various formulations of the vaccines. Serum samples were collected at the beginning and at 1, 2, and 3 months post vaccination. Mean neutralizing antibody titers (MNA) against PPRV and MNA along with complement fixing (CF) antibody titers against FMD "O" in the serum samples were measured to test the efficacy of the vaccines. Live attenuated wet, gel and oil based PPR vaccines induced 229.2 (±112.79), 253.6(±83.05), and 424 (±182.06) MNA titers in the goats after 3 months of vaccination. Similarly, animals inoculated non-adjuvant, gel based, and oil adjuvant FMD "O" vaccines developed 20(±4.35), 186.2 (±65.39), and 285.8 (±63.80) MNA and 0.4 (±0.894),22.4(±8.76) and 25.6(±8.7) CF antibody titers at 3 months post vaccination (PV). Bivalent (PPRV and FMDV) non adjuvant vaccine induced 249.6(±3.130) and 27.2(±14.53), gel based vaccine induced 306 (±99.82) and 296.2 (±58.21) while the oil based vaccine provoked 417.8 (±141.56) and 286 (±97.13) MNA titres against PPRV and FMD "O" virus respectively, at 3 months PV. Results of present study demonstrate that live attenuated PPRV vaccines can induce better immune response in comparison to killed FMD "O" virus vaccine. Addition of adjuvants is helpful to enhance the immunogenicity of the added antigens. While adjuvant bivalent vaccines containing PPRV and FMD "O" virus can effectively provoke equivalent antibody response against both of the immunogens in the vaccine. Antibody titee in response to Bivalent vaccine of PPR and FMD seotype"O" containing oil as an adjuvant was superior to gel adjuvant and non adjuvant bivalent vaccines. There was poor immune response of goats to non adjuvant FMD"O" vaccines. |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical Term | Department of Microbiology |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Prof. Dr. Khushi Mohammad |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | Thesis |
| Damaged status | Collection code | Permanent Location | Current Location | Shelving location | Date acquired | Full call number | Accession Number | Koha item type |
|---|---|---|---|---|---|---|---|---|
| Veterinary Science | UVAS Library | UVAS Library | Thesis Section | 2015-05-29 | 1698,T | 1698,T | Thesis |