| Dissertation note |
This project was designed to determine the pharmacokinetic parameters of different dosage forms of potassium iodide in healthy human volunteers and also to compare the pharmacokinetic parameters of potassium iodide in healthy male and female volunteers. For this study 36 healthy volunteers were selected (Divided into three groups, 6 male and 6 female in each group). Only those volunteers who were between ages 20-35 were selected, not suffering from any disease. Volunteers were clearly informed about the objectives of study and written consent was taken. Healthy volunteers were divided in to three equal groups and were given capsule, solution, powder dosage form of potassium iodide respectively through oral route. 5ml blood samples were collected at 0, 0.25, 0.5, 1.0, 1.5, 2.0, 2.5, 3.0, 4.0, 6.0, 8.0, 10, 12, and 24 hours from vein of either arm with I/v branula. Plasma was separated by centrifugation at 3000 RPM for 10 minutes and was stored at -80 0C till analysis. Method for the determination of potassium iodide was validated appropriately and analysis of samples was performed on HPLC. All pharmacokinetic parameters were calculated by entering plasma concentration-time data in excel based software PK solutions version 2.0. Pharmacokinetic parameters of potassium iodide in healthy individuals were studied by using statistical tests mean ± SD (standard deviation) and One Way ANOVA. Pharmacokinetic comparison of different dosage forms of potassium iodide in healthy male and female volunteers was studied by unpaired t-test. Results were summarized in tables. Between the dosage forms there is significant difference in the pharmacokinetic parameters of healthy human volunteers but there was no significant difference found in pharmacokinetic parameters between healthy male and female volunteers in each dosage form.
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