Evaluation Of Lipid Lowering Effect Of Terminalia Chebula In Hyperlipidemic Patients
By: Abdur Rehman (2013-VA-780)
| Dr. Muhammad Nasir.
Contributor(s): Dr. Zubair Farooq | Dr. Aqeel Javeed.
Material type: 
BookPublisher: 2016Description: 60p.Subject(s): Food and NutritionDDC classification: 2716-T Dissertation note: Hyperlipidemia is regarded as leading cause of cardiovascular diseases and atherosclerosis and found to be best recognized modifiable factor for heart diseases and atherosclerosis. The present study constitutes on T. chebulahaving hypolipidemic activity. Sixty patients were studied in four groups and treated with T.chebula (150 mg hydroalcholicextract) for group 1 (15 patients), T.chebula(150mg hydroalcholic extract) + Atorvastatin (10 mg) for group 2 (15 patients), T. chebula (75 mg hydroalcholic extract) + Atorvastatin (5 mg) for group 3 and Atorvastatin (10 mg) for group 4 respectively for 12 weeks. The primary endpoints were mean changes in LDL-C, VLDL-C, HDL-C, Triglycerides and Total Cholesterol levels at 0, 30, 60 and 90 days. Data are expressed as means ± standard error of mean (SEM) and minimum – maximum and was analyzed using Descriptive Statistics and Repetitive Measures. Values of p<0.05 were considered statistically significant.The hydroalcoholic extract of T. chebula exhibits significant hypolipidemic activity when applied in different doses as compared to statin group. Lipid parameters like Cholesterol, Triglycerides, LDL and VLDL were decreased in all the 4 designed groups. However the statin groups have relatively high potential of decreasing Cholesterol, Triglycerides, LDL and VLDL when compared with the results of T. chebula extract. Group 3 have least hypolipidemic activity. Group 2 receiving exhibits highest results when compared with all the other 3 groups. Group 1 has the ability to significantly decrease Cholesterol, Triglycerides, LDL and VLDL when compared with group 4. Group 4 was taken as standard and found to significantly reduce the all lipid parameters used during the study.These results suggests a pharmacological indication on the traditional uses of T. chebula pericarp for hyperlipidemia and it can be determined that T. chebulahave a strong ability to reduce high lipid profile. The findings of proposed research are helpful in reducing modifiable risk factor for cardiovascular diseases.
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Thesis
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UVAS Library Thesis Section | Veterinary Science | 2716-T (Browse shelf) | Available | 2716-T |
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Hyperlipidemia is regarded as leading cause of cardiovascular diseases and atherosclerosis and found to be best recognized modifiable factor for heart diseases and atherosclerosis. The present study constitutes on T. chebulahaving hypolipidemic activity. Sixty patients were studied in four groups and treated with T.chebula (150 mg hydroalcholicextract) for group 1 (15 patients), T.chebula(150mg hydroalcholic extract) + Atorvastatin (10 mg) for group 2 (15 patients), T. chebula (75 mg hydroalcholic extract) + Atorvastatin (5 mg) for group 3 and Atorvastatin (10 mg) for group 4 respectively for 12 weeks. The primary endpoints were mean changes in LDL-C, VLDL-C, HDL-C, Triglycerides and Total Cholesterol levels at 0, 30, 60 and 90 days. Data are expressed as means ± standard error of mean (SEM) and minimum – maximum and was analyzed using Descriptive Statistics and Repetitive Measures. Values of p<0.05 were considered statistically significant.The hydroalcoholic extract of T. chebula exhibits significant hypolipidemic activity when applied in different doses as compared to statin group. Lipid parameters like Cholesterol, Triglycerides, LDL and VLDL were decreased in all the 4 designed groups. However the statin groups have relatively high potential of decreasing Cholesterol, Triglycerides, LDL and VLDL when compared with the results of T. chebula extract. Group 3 have least hypolipidemic activity. Group 2 receiving exhibits highest results when compared with all the other 3 groups. Group 1 has the ability to significantly decrease Cholesterol, Triglycerides, LDL and VLDL when compared with group 4. Group 4 was taken as standard and found to significantly reduce the all lipid parameters used during the study.These results suggests a pharmacological indication on the traditional uses of T. chebula pericarp for hyperlipidemia and it can be determined that T. chebulahave a strong ability to reduce high lipid profile. The findings of proposed research are helpful in reducing modifiable risk factor for cardiovascular diseases.
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