Effect Of Sub Chronic Exposure Of Low Doses Of Bisphenol A On Anthropometric Parameters And Lipid Profile In Rats
By: Sayeda Iqra Ahmad (2011-VA-433)
| Dr. Khalid Abdul Majeed.
Contributor(s): Dr. Muhammad Shahbaz Yousaf | Ms. Amina Chughtai.
Material type: 
BookPublisher: 2017Description: 45p.Subject(s): PhysiologyDDC classification: 2868-T Dissertation note: Bisphenol A is an endocrine disruptor. It is monomer of polystyrene and a basic component of epoxy resins. It is carcinogenic in nature and has adverse impact on health of different animals as wells as human beings. It harms the reproductive, renal system as well as a basic reason of metabolic syndrome. The aim of this study is to assess the effect of sub chronic exposure of Bisphenol A on anthropometric parameters and lipid profile in rats
Bisphenol A may elevate serum lipid profile level and increase the ratio of anthropometric parameters in rats.
Forty eight albino rats half male and half females of similar age and weight were selected. They were divided into three groups each having sixteen rats in each (8 males,8 females) and named as Group A, B and C for experimental trial of three months. Group A was referred as control group treated with only basal diet and water. Group B was treated with 0.1mg/kg (body weight) BPA with basal diet and water. Group C was treated with 1mg/kg (body weight) BPA with basal diet and water. After three months blood sample was collected by euthanizing the rats to obtain serum sample for biochemical analysis and at the same time anthropometric values were noted.
Data was analyzed via two way ANOVA using SPSS software and Post hocTukey test was applied to study and compare differences between the groups. The p value <0.05 was assumed as significant value.
At the end of this trialour studies suggest thatthe effect of Bisphenol A increased the ratio of anthropometric parameters up to a certain limit as well as it significantly effects the all nutritional parameters. It highly effectsthe concentration of HDL in serum lipid profile.
It disturbs the concentration of ALP and AST at low doses while ALT had no significant effects due to BPA. It had no significant influences on kidney metabolites e.g., creatinine urea and BUN. Glucose concentrationalso not showed any profound effect in male and female albino rats.
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Thesis
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UVAS Library Thesis Section | Veterinary Science | 2868-T (Browse shelf) | Available | 2868-T |
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Bisphenol A is an endocrine disruptor. It is monomer of polystyrene and a basic component of epoxy resins. It is carcinogenic in nature and has adverse impact on health of different animals as wells as human beings. It harms the reproductive, renal system as well as a basic reason of metabolic syndrome. The aim of this study is to assess the effect of sub chronic exposure of Bisphenol A on anthropometric parameters and lipid profile in rats
Bisphenol A may elevate serum lipid profile level and increase the ratio of anthropometric parameters in rats.
Forty eight albino rats half male and half females of similar age and weight were selected. They were divided into three groups each having sixteen rats in each (8 males,8 females) and named as Group A, B and C for experimental trial of three months. Group A was referred as control group treated with only basal diet and water. Group B was treated with 0.1mg/kg (body weight) BPA with basal diet and water. Group C was treated with 1mg/kg (body weight) BPA with basal diet and water. After three months blood sample was collected by euthanizing the rats to obtain serum sample for biochemical analysis and at the same time anthropometric values were noted.
Data was analyzed via two way ANOVA using SPSS software and Post hocTukey test was applied to study and compare differences between the groups. The p value <0.05 was assumed as significant value.
At the end of this trialour studies suggest thatthe effect of Bisphenol A increased the ratio of anthropometric parameters up to a certain limit as well as it significantly effects the all nutritional parameters. It highly effectsthe concentration of HDL in serum lipid profile.
It disturbs the concentration of ALP and AST at low doses while ALT had no significant effects due to BPA. It had no significant influences on kidney metabolites e.g., creatinine urea and BUN. Glucose concentrationalso not showed any profound effect in male and female albino rats.
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