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Study On Whole Blood Xenotransfusion In Domestic Cats

By: Ihtesham Yousaf (2015-VA-17) | Dr. Uzma Farid Durrani.
Contributor(s): Dr. Asim Khalid Mahmood | Dr. Raheela Akhtar.
Material type: materialTypeLabelBookPublisher: 2017Description: 38p.Subject(s): Pet Animal PracticesDDC classification: 2944-T Dissertation note: Cat is the most domesticated pet all over the world. However, there are numerous clinical emergency situations of cats which require immediate blood transfusion but due to limited availability of cat blood donors;it becomes challenging for practitioners to save the patient’s life.In case ofdire need of blood transfusion when feline blood is unavailable; xenotransfusion with canine blood can be attempted. Xenotransfusionrefers to thetransfusion of blood from one species to another species. The present study was conducted on 20 rescue domestic cats divided into two groups: i.e. Experimental group and control group, each with 10 cats. In experimental group blood of 10 clinically healthy German Shepherddogs (donor) was transfused to10 adult rescue domestic cats suffering severe accidental blood loss. Control group received 0.9% normal saline infusion. Pre and post blood transfusion hematological evaluation was done for each recipient cat on days 0, 1, 3 and 7. Parameters for hematological evaluation included complete blood count, CRT, SpO2and arterial blood pressure.Obtained data was statistically analyzed by repeated measures of analysis of variance (ANOVA) within control and experimental group while between groups data was statistically analyzed using independent sample t-test.On the basis of findings of this study xeno-transfusion is proved to be a safe and effective life saving technique for cats suffering critical blood loss.
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Cat is the most domesticated pet all over the world. However, there are numerous clinical emergency situations of cats which require immediate blood transfusion but due to limited availability of cat blood donors;it becomes challenging for practitioners to save the patient’s life.In case ofdire need of blood transfusion when feline blood is unavailable; xenotransfusion with canine blood can be attempted. Xenotransfusionrefers to thetransfusion of blood from one species to another species.
The present study was conducted on 20 rescue domestic cats divided into two groups: i.e. Experimental group and control group, each with 10 cats. In experimental group blood of 10 clinically healthy German Shepherddogs (donor) was transfused to10 adult rescue domestic cats suffering severe accidental blood loss. Control group received 0.9% normal saline infusion. Pre and post blood transfusion hematological evaluation was done for each recipient cat on
days 0, 1, 3 and 7. Parameters for hematological evaluation included complete blood count, CRT, SpO2and arterial blood pressure.Obtained data was statistically analyzed by repeated measures of analysis of variance (ANOVA) within control and experimental group while between groups data was statistically analyzed using independent sample t-test.On the basis of findings of this study xeno-transfusion is proved to be a safe and effective life saving technique for cats suffering critical blood loss.

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