This project was designed to find out the prevalance and chemotherapy of coccidiosis in sheep and goats and its effect on certain blood parameters like Haemoglobin, TLC, DLC, Glucose,and Total Serum Protein.

Two drugs namely suiphadimidine and suiphaqunoxaline were used in this research project. For this purpose 60 animals(i.e sheep and goats) were taken and divided into 3 groups(A,B and C) containing 20 animals each(i.e 10 sheep and 10 goats). Group A was again subdivided into two subgroups Ag & As containing 10 animals each(i.e 10 goats and 10 sheeps) were treated with sulphadimidine.Group B was again subdivided into two subgroups Bg & Bs containing 10 animals each(i.e 10 goats and 10 sheeps) were treated with suiphaquinoxaline. Group C was again subdivided into two subgroups Cg & Cs containing 10 animals each (i.e 10 goats and 10 sheeps) were kept as infected non.medicated control.

The efficacy of drugs were determined on the reduction of OPG in faeces.

From the results it is find out that the average OPG on zero day of medication in groups i.e Ag,As & Bg,Bs were 75100, 72200, 60800 & 67200 respectively.The average reduction of OPG on 10th day of medication in groups i.e Ag,As & Bg,Bs were 300,340,120 & 280 respectively.The OPG of control groups were increased on the subsequent days.

The average Haemoglobin on zero day of medication in groups Ag,As,& Bg,Bs were 6.53,8.02,6. 89 & 7.93 respectively The average Haemoglobin on lOtti day of medication in groups Ag,As,Bg,Ss were 8.628.80, 9.44 & 8.78 respectively.The Haemglobin of the control groups were decreased on subsequent days. Average TLC on zero day of medication in groups Ag,As,Bg,Bs were 16.50 ,16.50 & 15.50,19.50.Average TLC on 10th day of medication in groups Ag,As & Bg,Bs were 14.50,12.90 & 13.60,13.50 respectively.The TLC of control groups were increased on the subsequent days.Average DLC on zero day of medication in groups Ag was 49.40,68.00,7.00 11.10 & 17.50 in group Bg was 51.20 ,70.30,6.90, 12.20 & 19.40 in group As was 50.20,70.20,8.00,12.00 & 18.50 in group Bs was 50.40.71.60,6.10,17.20 & 18.40 .Average DLC on 10th day of medication in groups Ag was 48.40,67.00,7.00 11.10 & 17.50 in group Bg was 50.20 ,69.30,7.10,12.20 & 19.40.ln Group As was 49.40,69.10,8.00,12.00 & 18.50 in group Bs was 49.40,70.60,6.10,17.20,18.40.DLC of the control groups were incresed on the subsequent days. Average Blood Glucose on zero day of medication in groups Ag,As,Bg,Bs were 24.30, 31.30 & 29.30, 35.50 respectively.Average Blood Glucose on 10th day of medication in groups Ag,As,Bg,Bs were 37.00, 42.40, 42.80, 45.00. Blood glucose in control were decreased on the subsequent days. Average Total Serum protein on zero day of medication in groups Ag,As & Bg,Bs were 3.52,4.25,3.93,4.18. Average Total Serum protein on 10 th day of medication in groups Ag,As,Bg,Bs were 4.89,5.56 & 5.43,5.57 respectively.The total serum protein in control groups were decreased on the susequent days.