Studies On Sodium Alginate And Other Adjuvants For Improving Efficacy Of Haemorrhagic Septicaemia Vaccine
By: Khalid Mahmood Shad
| Dr . Muhammad Akram Munir.
Contributor(s): Dr . Haji Ahmad | Dr . Muhammad Amin Sheikh | Faculty of Veterinary Sciences.
Material type: 
BookPublisher: 1998Subject(s): Department of MicrobiologyDDC classification: 0697,T Dissertation note: The present study was conducted on 80 cow and buffalo calves to determine the effect of incorporation of sodium alginate, potassium aluminum sulphate and liquid paraffin on the immunogenicity of H.S. vaccines. The study was carried out 3 months old cow calves and buffalo calves (40 each). The calves were divided into four groups i.e. A, B, C and D comprising ten animals of each species. Group B, C and D were innoculated with oil adjuvants vaccine, potassium aluminium sulphate vaccine and sodium alignate vaccine respectively, while group A wa kept unvaccinated control. The blood samples were collected for IHA antibody titre on day one i.e. before vaccination and then fortnightly post vaccination till the end of the project i.e. 90th day.
The IHA antibody titre of all experimental animals on day one was nearly same ranging from GMT 7.20-11.20. After vaccination IHA antibody titre rose, in all groups of vaccinated animals of both species to GMT 192.00-204.80, 128.00-147.00 and 108.00 in groups B, C and D, respectively. The maximum GMT antibody titre was observed in group B followed by D and C. The IHA antibody titre in group A remained nearly the same as on day 1. The antibody titre was significantly higher (P<0.01) in vaccinated groups than non vaccinated group. While in group B (OAV) IHA antibody titre was significantly higher (P<0.05) than group C (PAV) and D (SAV). But the plus point with SAV is that, it is very simple to prepared, easy to stoe and administred, and have a longer shelf life.
From these findings it can be concluded that oil adjuvant vaccine provided better immunity to both buffalo calves and cow calves, as only one shot of this vaccine could protect an animal for one year. However, there is need for further investigation.
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Thesis
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UVAS Library Thesis Section | Veterinary Science | 0697,T (Browse shelf) | Available | 0697,T |
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The present study was conducted on 80 cow and buffalo calves to determine the effect of incorporation of sodium alginate, potassium aluminum sulphate and liquid paraffin on the immunogenicity of H.S. vaccines. The study was carried out 3 months old cow calves and buffalo calves (40 each). The calves were divided into four groups i.e. A, B, C and D comprising ten animals of each species. Group B, C and D were innoculated with oil adjuvants vaccine, potassium aluminium sulphate vaccine and sodium alignate vaccine respectively, while group A wa kept unvaccinated control. The blood samples were collected for IHA antibody titre on day one i.e. before vaccination and then fortnightly post vaccination till the end of the project i.e. 90th day.
The IHA antibody titre of all experimental animals on day one was nearly same ranging from GMT 7.20-11.20. After vaccination IHA antibody titre rose, in all groups of vaccinated animals of both species to GMT 192.00-204.80, 128.00-147.00 and 108.00 in groups B, C and D, respectively. The maximum GMT antibody titre was observed in group B followed by D and C. The IHA antibody titre in group A remained nearly the same as on day 1. The antibody titre was significantly higher (P<0.01) in vaccinated groups than non vaccinated group. While in group B (OAV) IHA antibody titre was significantly higher (P<0.05) than group C (PAV) and D (SAV). But the plus point with SAV is that, it is very simple to prepared, easy to stoe and administred, and have a longer shelf life.
From these findings it can be concluded that oil adjuvant vaccine provided better immunity to both buffalo calves and cow calves, as only one shot of this vaccine could protect an animal for one year. However, there is need for further investigation.
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