Passive Immunization Of Avian Influenza Virus Infected Broiler Chicks
By: Muhamad Mahmood Mukhtar
| Dr. Masood RAbbani.
Contributor(s): Dr. Khushi Muhammad | Dr. Shakil | Faculty of Veterinary Sciences.
Material type: 
BookPublisher: 2002Subject(s): Department of MicrobiologyDDC classification: 0776,T Dissertation note: Present study was conducted to determine the contribution of passive immunization against avian influenza disease. In this study, ten layer birds were vaccinated thrice at 21 days interval, using oil based avian influenza v irus (AIV: H7 type) vaccine. A high titer of anti-Al V-antibodies in blood serum and egg yolk of these birds was determined on 20(11 day post-boosting using haemagglutination inhibition (HI) test. A virulent avian influenza virus (H7 type) with mean embryo infective dose (E1D50) of l0 was used for challenging the birds. The hyperimmune serum and hyperimmune egg yolk (1ml, 128 HI units) injected to avian influenza virus (H7 type) challenged broiler chicks showed 100% protection as compared to that of virus control group (given I ml of 0 HI units of serum and yolk). Moreover, it was found suitable to passively immunize the birds before exposure or simultaneously with the exposure of avian influenza virus. The cost of the production of hyperimmune egg yolk was calculated as Rs. 0.43 per dose (1ml: 128 HI units), which was quite economical as compared to other chemotherapies. It is concluded that the hyperimmune serum and hyperimmune yolk can therapeutically be used to cure the avian influenza virus (H7 type) infected birds.
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Thesis
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UVAS Library Thesis Section | Veterinary Science | 0776,T (Browse shelf) | Available | 0776,T |
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Present study was conducted to determine the contribution of passive immunization against avian influenza disease. In this study, ten layer birds were vaccinated thrice at 21 days interval, using oil based avian influenza v irus (AIV: H7 type) vaccine. A high titer of anti-Al V-antibodies in blood serum and egg yolk of these birds was determined on 20(11 day post-boosting using haemagglutination inhibition (HI) test. A virulent avian influenza virus (H7 type) with mean embryo infective dose (E1D50) of l0 was used for challenging the birds. The hyperimmune serum and hyperimmune egg yolk (1ml, 128 HI units) injected to avian influenza virus (H7 type) challenged broiler chicks showed 100% protection as compared to that of virus control group (given I ml of 0 HI units of serum and yolk). Moreover, it was found suitable to passively immunize the birds before exposure or simultaneously with the exposure of avian influenza virus. The cost of the production of hyperimmune egg yolk was calculated as Rs. 0.43 per dose (1ml: 128 HI units), which was quite economical as compared to other chemotherapies. It is concluded that the hyperimmune serum and hyperimmune yolk can therapeutically be used to cure the avian influenza virus (H7 type) infected birds.
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