This study was carried out on 40 postpartum buffaloes suffering from endometritis with the objective that if gentamicin (@ 4mg/kg body weight, I/M) or enrofloxacin (@ 5mg/kg body weight, I/M) for 3 consecutive days is effective against the endometritis. Twenty postpartum, untreated, healthy buffaloes were kept as control (group C). The uterine characteristics and blood samples for haematological studies were examined before (day 0) and after treatment (day 4). Mucus samples were examined for fern pattern at first estrus before treatment and after treatment. Both the treatment did not differ significantly (P> 0.05) among them; however, they had significantly (P< 0.05) beneficial effect on cervical diameter, location of uterus, texture of uterine wall and symmetry of uterine horns. Intensity of uterine infection was cured sigtnificantly. The haematological values revealed a significant improvement (P<0.05 in EST, Hb and TLC in endometritic animals (group A and B) but the difference was non significant in control group. Whereas value of TEC was non significant in group A and C and significant improvement was observed in group B after treatment. Moreover, when we compare the 3 groups (A,B and C) to each other, non significant difference was observed among the Hb concentration in three groups. Whereas, ESr was not significant between group A,B and C, but was significant between groups B and C (P<0.05). in TEC, the values were significant difference in group A with C group B with group C. but no significant difference in group A with group B. and in TLC, there was significant difference in group A with group B and group ?A with group C, but no significant difference in group B with group C. similarly in DLC the values of eosinophils were significant in group A. but no significant difference in group B and group C in before and after treatment. In neutrophils, there were significant differences in values of group B but no significant difference in group A and group C. also in lymphocytes, significant difference was found in group B, but was not no significant difference in group A and C in before and after treatment. As in basophils, monocytes, there was no significant difference in before treatment and after treatment. Furthermore, when these DLC value were compare with each other after treatment, there was significant difference in neutrophils and lymphocytes within group A with B, A with C and B with C. in monocytes, significant difference was found in A with C group and group B with C, but no significant difference in A with B. In eosinophils, no significant difference was found in all three groups. And in basophils, significant difference was found in group A with C and B with C. but no significant difference in A group with B group. The physical signs (uterine tone, vulvular swelling, hyperemia, and wetness in vagina, switching of tail, mucus discharge) and behavioural signs (Micruration, rising of tail, bellowing, mounting and restlessness of estrus were studied. After treatment estrus was observed in 45% of group A and 55% of group B buffaloes. The pregnancy rate was 60% in group A and 50% in group B buffaloes. This was comparable to the pregnancy rate in group C buffaloes (62%). And there were no significant difference in the conception rates. It is concluded that both gentamicin and enrofloxacin are equally effective for the treatment of postpartum endometritic buffaloes.