Efficacy Of Livergen And Icterene Aginst Experimentally Induced Hepatotoxicity In Rabbits
By: Ahmed Sardar Mirza
| Prof.Dr.Muhammad Ashraf.
Contributor(s): Dr. Muhammad Ovais Omer | Prof.Dr.
Material type: 
BookPublisher: 2004Subject(s): Department of Pharmaoclogy & ToxicologyDDC classification: 0915,T Dissertation note: The study was conducted on 35 male rabbits weighing from 1-1.5 kg. The study was carried out on the basis of elevation and decline in the levels of Alanine Transminase (ALT/SGPT), Aspartate Transminase (AST/SGOT) by inducing experimental hepatic injury by paracetamol and then treating it with hepatoprortective agents like, Livergen, Icterene and Jetepar. The rabbits were divided into the seven group i.e. A, B, C, D, E, F and G. All animals except animals of group A which is a control group were administered with hepatotoxic dose of paracetamol 2.5g/kg at day zero, while group C, D and E received hepatoprotective dose of Livergen syrup 1ml, 2ml and 3ml/kg respectively at day 2 for five consecutive days in addition to the toxic dose of paracetamol at day zero. The animals of group F received hepatoprotective dose of Icterene tablets 140mg/kg at day 2 for 5 consecutive days in addition to paracetamol toxic dose at day zero. The animals of group G received hepatoprotective dose of Jetepar syrup 1ml/kg at day 2 for five consecutive days in addition to the hepatotoxic dose of paracetamol 2.5g/kg at day zero. The blood samples were collected at day 0, 1, 2, 4, 6, 8 and 10. Concludingly, the drug Jetapar was found to be best effective. While Livergen and Icteren showed equal effective results at normal dose but significantly less than Jetepar. However, Livergen at dose 2ml/kg and 3ml/kg showed equal but almost similar results to Jetepar at last day.
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Thesis
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UVAS Library Thesis Section | Veterinary Science | 0915,T (Browse shelf) | Available | 0915,T |
The study was conducted on 35 male rabbits weighing from 1-1.5 kg. The study was carried out on the basis of elevation and decline in the levels of Alanine Transminase (ALT/SGPT), Aspartate Transminase (AST/SGOT) by inducing experimental hepatic injury by paracetamol and then treating it with hepatoprortective agents like, Livergen, Icterene and Jetepar. The rabbits were divided into the seven group i.e. A, B, C, D, E, F and G. All animals except animals of group A which is a control group were administered with hepatotoxic dose of paracetamol 2.5g/kg at day zero, while group C, D and E received hepatoprotective dose of Livergen syrup 1ml, 2ml and 3ml/kg respectively at day 2 for five consecutive days in addition to the toxic dose of paracetamol at day zero. The animals of group F received hepatoprotective dose of Icterene tablets 140mg/kg at day 2 for 5 consecutive days in addition to paracetamol toxic dose at day zero. The animals of group G received hepatoprotective dose of Jetepar syrup 1ml/kg at day 2 for five consecutive days in addition to the hepatotoxic dose of paracetamol 2.5g/kg at day zero. The blood samples were collected at day 0, 1, 2, 4, 6, 8 and 10. Concludingly, the drug Jetapar was found to be best effective. While Livergen and Icteren showed equal effective results at normal dose but significantly less than Jetepar. However, Livergen at dose 2ml/kg and 3ml/kg showed equal but almost similar results to Jetepar at last day.
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