1.
Effectiveness Of Chemotherapeutic Agents In Recovery And Elimination Of Carrier State Of Burkholderia Mallei
by Aslam zab | Dr. Syed Saleem ahmad | Dr. Jawaria ali khan | Dr. Sadaf aslam.
Material type: ; Format:
print
; Literary form:
drama
Publisher: 2014Dissertation note: Abstract Availability: Items available for loan: UVAS Library [Call number: 1882,T] (1).
2.
Comparative Efficacy Of Flank And Midline Approach For Nephrotomy In Dogs
by Aamir Noor | Prof.Dr. Muhammad Arif | Dr. Jawaria Ali Khan | Dr. Sadaf Aslam.
Material type: ; Format:
print
; Literary form:
not fiction
Publisher: 2014Dissertation note: Abstract Availability: Items available for loan: UVAS Library [Call number: 2152,T] (1).
3.
Comparison Of Intravenous And Inhalation Anesthesia For Performing Minor And Major Surgeries In Sheep And Goat
by Muhammad Imran Ibraheem (2006-VA-108) | Dr. Sadaf Aslam | Dr. Uzma Farid Durrani | Dr. Hafsa Zainab.
Material type: ; Literary form:
not fiction
Publisher: 2015Dissertation note: Anesthesia can be achieved with injection or inhalation of substances that produce
reversible state of unconsciousness. For scientific quality, anesthetic technique must be reliable
and safe and the effects, of anesthetic compounds on animals must be well documented. If
animals undergo survival surgery, they need to recover quickly and not suffer unnecessarily
disturbance in biological parameters. This is of importance for both animal welfare and scientific
quality.
Awareness among animal lovers and increase in value of animals, the impedance has
increased to many folds on surgeons to select ideal anesthetics for ideal outcomes during major
surgical interventions. The anesthetic agents should be standardized for minimal recovery time in
animals, so that the animals have to bear minimum cardiovascular, hepatic and renal distress due
to different anesthetic drugs used.
The present study was carried out on twelve sheep and goats. The selection criteria was
surgical cases presented for minor and major surgeries at Indoor Surgery Clinic, UVAS, Lahore.
All surgical cases were subjected into two treatment groups, viz. group A and B comprising six
surgical cases in each group. In group (A) animals were given Xylazine @2.2mg/kg (Xylaz;
Farvet, Holland) as a preanesthetic followed by Ketamine @2-4mg/kg (Ketarol; Global pharma,
Pakistan) as anesthetic and maintenance whereas group (B) animals were given xylazine
@2.2mg/kg as preanesthetic and afterwards induction and maintenance were performed with
Isoflurane (4%) (Forane; Abbott, Pakistan) inhalation anesthesia with oxygen flow rate of (3
L/min)
……………………………………………………………………………………………………………………………………………SUMMARY
63
The overall objective of this study was to evaluate the effect of xylazine, ketamine and
isoflurane gas anesthesia on different biological systems of body. Comparison among different
drugs was evaluated during minor and major surgeries in sheep and goat. The parameters used to
evaluate the efficacy of these anesthetic drugs exposed that isoflurane has less outcome on
cardiovascular, liver and renal system. In adding together it has an edge over other injectable
anesthetic drugs on account of its undetrimental effect on other physiological parameters of
animals. Clinical trials have proved that isoflurane a narrative anesthetic agent is a drug of choice
in minor as well as major surgical procedures without any injurious effects.
Conclusion:
The mean value of specific all parameters TPR, LFT and RFT and CBC shows that Injectable
xylazine and ketamine was not safe. Isoflurane anesthesia was the safest anesthetic agent in
geriatric or weak animals for longer procedure. Availability: Items available for loan: UVAS Library [Call number: 2273-T] (1).
4.
A Sonographic Diagnostic Study Of Tendinopathies And Traumatic Injuries Of Joints And Associated Soft Tissue Structures In Equines In And Around Lahore
by Azmat Ullah (2013-VA-440) | Dr. Shehla Gul Bokhari | Dr. Sadaf Aslam | Dr. Saima Masood.
Material type: ; Literary form:
not fiction
Publisher: 2015Dissertation note: Diagnostic ultrasound was introduced as diagnostic modality in equines in 1982 by Rantanen. Horses are widely used across Pakistan for polo, race and draught purpose. Tendinopathies along with associated arthropathies and / or soft tissue trauma are common aliments among feet problems. However, no work has been done so far in Pakistan regarding the precise sonographic diagnosis of these problems and the seat of lameness, which results in the early culling of these horses. Advancements in diagnostic imaging have greatly improved the efficiency of the veterinarians in diagnosing soft tissues abnormalities. The present project was aimed to addressed these issues regarding precise lameness diagnosis in equines, with respect to sonographic presentation of the tendons, soft tissues and associated joints, and hence, to initiate precise diagnosis for effective treatment in future.
The study was designed to precisely diagnose and characterize the soft tissue injuries occurring concurrently with joint involvement, in the three predominant categories of horses in and around Lahore, viz., Race, Polo and draught-purpose.
For this purpose, twenty-four horses were divided into three groups i.e. A, B and C, each group comprising eight horses. Furthermore, each group were subdivided into two subgroups with four clinically sound horses and four unsound horses presented with soft tissues abnormalities occurring concurrently with or without joint involvement. The changes between sound and unsound structures were compared through intra-group and inter-group comparison.
The study was aimed towards practical needs in addressing to the precise sonographic diagnosis for the seat of lameness and characterization of the lesion. Conclusively, percentage
Summary
64
occurrence and degree of prognosis were assessed. Besides, it will futuristically augment in proper treatment of our precious animals.
Different soft tissue structures of various joints (elbow, carpus, MCP/MCT, stifle, and hock) were sonographically imaged both in sound and unsound horses for the percentage occurences of injuries in all the three group, along with degree of lameness, degree of pain, degree of range of motion in each joint and degree of prognosis. The parameters shown significant correlation with minor differences.
The study proved that occurrence of tendinopathies and associated joint trauma are more common in race horses than in polo and draught-purpose horses. The data regarding sonography of the joints was analyzed by using chi square test with the help of SPSS version 17.
The study can be used as a proven tool for the early diagnosis, prognosis of soft tissue abnormalities and facilitate both veterinarians and owners in long run and can also be used for treatment purposes.Diagnostic ultrasound was introduced as diagnostic modality in equines in 1982 by Rantanen. Horses are widely used across Pakistan for polo, race and draught purpose. Tendinopathies along with associated arthropathies and / or soft tissue trauma are common aliments among feet problems. However, no work has been done so far in Pakistan regarding the precise sonographic diagnosis of these problems and the seat of lameness, which results in the early culling of these horses. Advancements in diagnostic imaging have greatly improved the efficiency of the veterinarians in diagnosing soft tissues abnormalities. The present project was aimed to addressed these issues regarding precise lameness diagnosis in equines, with respect to sonographic presentation of the tendons, soft tissues and associated joints, and hence, to initiate precise diagnosis for effective treatment in future.
The study was designed to precisely diagnose and characterize the soft tissue injuries occurring concurrently with joint involvement, in the three predominant categories of horses in and around Lahore, viz., Race, Polo and draught-purpose.
For this purpose, twenty-four horses were divided into three groups i.e. A, B and C, each group comprising eight horses. Furthermore, each group were subdivided into two subgroups with four clinically sound horses and four unsound horses presented with soft tissues abnormalities occurring concurrently with or without joint involvement. The changes between sound and unsound structures were compared through intra-group and inter-group comparison.
The study was aimed towards practical needs in addressing to the precise sonographic diagnosis for the seat of lameness and characterization of the lesion. Conclusively, percentage
Summary
64
occurrence and degree of prognosis were assessed. Besides, it will futuristically augment in proper treatment of our precious animals.
Different soft tissue structures of various joints (elbow, carpus, MCP/MCT, stifle, and hock) were sonographically imaged both in sound and unsound horses for the percentage occurences of injuries in all the three group, along with degree of lameness, degree of pain, degree of range of motion in each joint and degree of prognosis. The parameters shown significant correlation with minor differences.
The study proved that occurrence of tendinopathies and associated joint trauma are more common in race horses than in polo and draught-purpose horses. The data regarding sonography of the joints was analyzed by using chi square test with the help of SPSS version 17.
The study can be used as a proven tool for the early diagnosis, prognosis of soft tissue abnormalities and facilitate both veterinarians and owners in long run and can also be used for treatment purposes. Availability: Items available for loan: UVAS Library [Call number: 2272-T] (1).
5.
Comparative Efficacy Of Injectable And Inhalation Anesthesia In Pigeons
by Matiur Rehman (2013-VA-858) | Dr. Sadaf Aslam | Dr. Uzma Farid Durrani | Dr. M. Ovais Omer.
Material type: ; Literary form:
not fiction
Publisher: 2015Dissertation note: General anesthesia is frequently used throughout the word in birds and experimental animals for different purposes. There are two techniques were used for general anesthesia, one is injectable and other is inhalational. Different drugs used for injectable anesthesia are ketamine, medetomidine, detomidine, xylazine etc. Drugs used for inhalational anesthesia include isoflurane, sevoflurane, nitrous oxide, halothane etc.
The present study was conducted to compared the different injectable and inhalational anesthetics for their effect on temperature, pulse rate, respiratory rate, induction time, anesthesia time, recovery duration and oxygen saturation in birds of different groups.
For this purposes 15 pigeons were selected and randomly divided into 3 groups A, B and C. Each group contained 5 pigeons. Group A was treated with ketamine, group B with xylazine and group C with isoflurane. After administration of these drugs with respect to their group then we noted the temperature, pulse rate and respiratory rate for every 15 min interval, and also noted the induction time, anesthesia time, and recovery duration for each group. Oxygen saturation was checked only in group C.
The result of our trial was that, the ketamine treated pigeons of group A showed hypothermia, bradycardia and respiratory depression. The induction and recovery was fast but rough while the duration of anesthesia was long.
The xylazine treated pigeons of group B also showed hypothermia, bradycardia and respiratory depression but their induction and recovery time was long and smooth. The muscles relaxation was present and there was low quality anesthesia, about all reflexes were present.
Summary
37
The birds of group C which were treated with isoflurane did not show any significant change in temperature, pulse rate, respiratory rate (TPR) and oxygen saturation. The induction and recovery both were fast and smooth. The duration of anesthesia was desirable, how long duration we need it gave the anesthesia of choice.
The present study proved that isoflurane was the best anesthetic for the painful and long surgeries. The muscles relaxation was good. It has no side effects. The effect of isoflurane on TPR was negligible. The induction and recovery both are rapid and smooth. By using isoflurane all reflexes were absent. The data of injectable and inhalational anesthesia was analysed by ANOVA ONE, least significant difference (LSD) in all groups and pair t test in group C with the help of SPSS version 20.
Isoflurane can be used as safe and durable anesthetic in pet birds as well as in animals. It has low cost as compared to other inhalant anesthetics like sevoflurane etc. It facilitate both owner and veterinarian in long run surgeries or other painful procedures.
The results of this study helped the surgeons to choose the effective anesthetics both injectable or inhalational for performing safe surgery or other painful procedures to avoid adverse effects of anesthetics in different clinically birds. Availability: Items available for loan: UVAS Library [Call number: 2395-T] (1).
6.
A Clinico-Biochemical Study On Different Pre-Anesthetic Drugs With Propofol For Neutering In Dogs
by Saba Siddique | Dr. Sadaf Aslam | Prof. Dr.M.Arif Khan | Dr. Raheela Akhtar.
Material type: ; Literary form:
not fiction
Publisher: 2016Dissertation note: The present research project was designed to study the effect of three routinely used
pre anaesthetic (alpha-2 adrenergic agonists) drugs xylazine (xylaz; 20 mg/ml, farvet, Holland)
and medetomidine (doiter, 1 mg/ml ; Orion pharma, finland), diazepam(Valium 0.25 mg/kg) and
propofol (pofol, 10 mg/ml ;Dongkook pharma, korea) anaesthesia in male dogs and castration
surgery was performed using pre scrotal approach. The effect of these sedative and anaesthetic
agents was studied at physical (temperature, pulse, and respiration), sedative (palpebral effect),
analgesic (tail pinch, toe pinch reflex), liver function (ALT, AST, and ALP), renal functions
(serum creatinine, BUN) and haematological (RBC, WBC, Hb) parameters. A total number of
twelve (12) dogs (mix breed) clinical cases were selected. These dogs were subjected into three
groups (A, B , C) each comprising four (4) dogs. Different drugs combination was administered
in each group of dogs. Three different drug combinations are;
Group A .Xylazine-Propofol
Group B. Diazepam-Propofol
Group C. Medetomidine-Propofol
Blood samples were taken at four different intervals like 0 minutes, 30 minutes, 60
minutes and after 24 hours in EDTA coated vacutainer for studying haematological parameters
and in lithium heparin vacutainer for evaluating biochemical parameters.
Results revealed that both sedative and anaesthetic agents produce slight non-significant changes
in liver enzymes but in case of renal function test, medetomidine-propofol produce significant
Summary
42
changes in serum creatinine and xylazine-propofol, and diazepam-propofol produce significant
changes in the values of blood urea nitrogen. Coming towards haematology, white blood cells
increase significantly in diazepam-propofol receiving group. The results of the present research
study were mostly similar with the findings of other scientists. The results of present project
were analysed by ANOVA followed by Turkey honestly significant difference (HSD) test.
Conclusion
The result of present project will prove fruitful for veterinary practioners for selectin
anaesthesia protocol for patients suffering from hepatitis or other liver, renal and haematological
problems and would be productive to solve the problems of anaesthetists who are actively
engaged in canine practice all over the world. On the basis of findings of this study it is
concluded that medetomidine-propofol combination gives better results. Availability: Items available for loan: UVAS Library [Call number: 2689-T] (1).
7.
Comparative Efficacy Of Xylocaine Hcl And Bupivacaine Hcl For Ophthalmic Anesthesia In Horses
by Muhammad Asad Islam (2012-VA-576) | Dr. Sadaf Aslam | Prof. Dr. Muhammad Arif Khan | Prof. Dr. Muhammad Sarwar Khan.
Material type: ; Literary form:
not fiction
Publisher: 2015Dissertation note: Ophthalmic procedures can be performed by many clinicians in horses using local nerve blocks by using local anaesthetics for short duration of action for completion of these procedures. These surgical procedures may involve exclusion of third eyelid, suturing of laceration around eye orbit and tumor which can be caused due to any reason with in time period of thirty minutes. Inner chamber centesis can be done easily by using the above mentioned technique in standing horse.
There are numerous benefits of doing standing surgical methods and avoiding general anaesthesia in horses. As hospitalizing horse may get other infectious diseases from surroundings like colitis and laminitis and also injured it when recovering from general anaesthesia. On the other hand standing surgical procedure reduced such complication by using local anaesthetic for short duration.
Bupivacaine Hcl gave an ideal local eye anaesthesia compare to xylocaine Hcl for standing surgical procedures in horses.
The present study was accomplished to assess the effectiveness of two local eye anaesthetics; xylocaine Hcl and bupivacaine Hcl by two different techniques i.e. retrobulbar technique and auriculopalpebral technique in horses. A total of 12 horses from indoor clinic and S.P.C.A were used in this study. These horses were subjected to two groups’ i.e. Group A and B. Each of these groups was further subdivided into two subgroups i.e. Group AI, AII and BI, BII respectively.
SUMMARY
42
Horses in group A were administered xylocaine Hcl through auriculopalpebral technique and retrobulbar technique. While horses of subgroup AI were given xylocaine Hcl by auriculopalpebral technique and horses in subgroup AII were injected xylocaine Hcl by retrobulbar technique.
Likewise horses in subgroup BI were given bupivacaine Hcl by auriculopalpebral technique, while those of subgroup BII were given bupivacaine Hcl through retrobulbar technique. The efficacy of above mentioned local anaesthetics was compared on the basis of Pattern of induction, Duration of anaesthesia and Recovery Pattern. Presence or absence of reflexes was also noted i.e. Pupillary Light Reflex and Blink reflex.
The data were analyzed through one way analysis of variance (ANOVA). The difference in group’s means was determined by Least Significant Difference (LSD) post-hoc test. A probability level of (P<0.05) was considered as statistically significantly difference. The statistical analysis was performed using statistical package for social science (SPSS) version16. Availability: Items available for loan: UVAS Library [Call number: 2679-T] (1).
8.
A Clinico-Biochemical Study Of Xylazine-Propofol,Meditomidine-Propofol, Diazepam-Propofol During Ovariohystrectomy Operationin Female Dogs
by Muhammad Ajmal (2006-VA-175) | Dr. Sadaf Aslam | Dr Ayesha Safdar | Dr. Nisar Ahmad.
Material type: ; Literary form:
not fiction
Publisher: 2016Dissertation note: Background:
Awareness among the small animals practitioner as the impedance has increased many fold on veterinary surgeons to select an ideal anesthetic provoking an ideal outcome during the ovariohystrectomy surgical interventions. The anesthesia should be selected in such a way that animal can recover from anesthesia early on and the operating room time for each patient be minimized in such a way that the animal bears minimum cardiovascular, hepatic, and renal changes due to different pre-anesthetic drugs used.
Hypothesis:
• Medetomidine-propofol might be better among all other three.
Parameters/Methodology:
For this study, fifteen dogs brought to the Pet center for ovariohystrectomywere selected, the
animalswere allocated into three treatment groups, viz. Groups A and Group B and Group C
with 5 animals each.
In group A animalsXylazineHCL was administered intramuscularly at the dose rate of 2.2mg/kgbody weight as pre anesthetic. After 3-5 minutes of preanesthetic injection propofol (6 mg/kg ofbody weight, IV) was injected. In group B, after surgical preparation, Medetomidine HCL in all the five dogs wasinjecting intramuscularly at the dose rate of 40 µg/kg body weight as pre anesthetics. After 3-5 minutes of pre anesthetic injection propofol (6 mg/kg of body weight, IV) was injected.
The dogs of group C Diazepam was injected intramuscularly (0.25 mg/kg) as pre
anesthetic. After 3-5 minutes of pre-anestheticinjectionpropofol (6 mg/kg of body weight, IV)
was injected.
Whilst regularly checking reflexes after short intervalsof time. After achieving of the
surgical stage of anesthesia, the surgical operation was begun.
Biochemical profile assessment was done for renal function tests (serum creatinine,
BUN) and live function tests (ALT, AST, and Alkaline phosphates).
Statistical Design:
The data wasanalyzed by One Way ANOVA followed by multiple comparison tests using
Statistical Package for Social Science (SPSS) version 20.0. The proportionate data was
analyzed through z-distribution test.
Outcome: Considering the significance of anesthesia in surgical interventions, this project was designed tostudy the effect new anesthesia combinations on cardiovascular system, renal and hepaticfunction for an efficacious and ideal pre-anesthetic combination for futuristic surgicalinterventions in dogs, with the aim to minimize surgical complications and accentuate early recovery.
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Availability: Items available for loan: UVAS Library [Call number: 2771-T] (1).
9.
Comparative Efficacy of Different Surgical Techniques and Suturing Patterns for Cystotomy in Rabbits
by Uroosa Anjum (2015-VA-601) | Prof. Dr. Muhammad Arif Khan | Dr. Sadaf Aslam | Dr. Raheela Akhtar.
Material type: ; Literary form:
not fiction
Publisher: 2017Dissertation note: CD Corrupt. Availability: Items available for loan: UVAS Library [Call number: 2814-T] (1).
