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Bioavailability And Pharmacokingetics Of Ampicillin In Volunteeers

by Naseer Ahmad | Prof.Dr.Muhammad Ashraf | Dr. Muhammad Ovais Omer.

Material type: book Book; Format: print ; Literary form: not fiction Publisher: 2001Dissertation note: The bioavailability and pharmacokinetics of ampicillin were investigated in six healthy male volunteers after intravenous and oral administration of penbritin 500mg and relative bioavailability of ampicap 500mg after oral administration. The blood samples were collected at various time intervals following administration of single dose of 500mg to each individual volunteer. The concentrations of ampicillin in serum samples were determined by using microbiological assay. The serum concentrations of ampicilin at different time intervals were plotted on semi-logarithmic graph paper. The bioavailabilty and pharmacokinetics parameters were calculated and expressed as mean + S.D. The peack oncerntration of 8.58+0.02 ug/ml reached in 2.30+0.002 hours after oral administration. By calculating the AUC i/v and AUC oral the bioavailability of penbritin 500mg oral was calculated and was 51.60+ 2.2.0 and that of ampicap was 50.00+10.00. The relative bioavailability (Bioequivalence ) of ampicap was determined by dividing the AUC (Ampicap) by AUC (penbritin) and it was 96.94+5.18%. Time to reach the maximum concerntration of penbritin orally was 2.30+0.002 and that of ampicap was 2.31+0.006 hours The half-live of elimination after i/v administration of penbritin was 1.005+0.00 hours, after oral administration was 1.21+0.001 hours and that of ampicap was 1.21+0.004, respectively. The volume of distribution after pendbritin i/v, penbritin orally and ampicap orally was 11.08+0.091, 25.92+0.76 and 26.64+0.82 liters, respectively. The total body clearance of penbritin was 127.84+10.53, 246.70+104.13 and 254.46+45.32 ml/minutres, respectively after penbritin i/v, penbritin orally and ampicap. Availability: Items available for loan: UVAS Library [Call number: 0812,T] (1).

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The Punjab Government rules of Business, 2011 (Amended up-to-date)

by Ch. Naseer Ahmad.

Edition: 1st ed.Material type: book Book; Format: print ; Literary form: not fiction Publisher: Lahore: Mansoor Book House; 2019Availability: Items available for loan: UVAS Library [Call number: 346.5491 Naseer 34164 1st 2019 Social.Science] (1).

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