000			02812nam a2200181Ia 4500
005			20151001145232.0
008			150525s2010 xx 000 0 und d
041			_aeng
082			_a1201,T
100			_aAmir Rashid _96705
110			_cDr. Sheryar Afzal _96706
245			_aPharmacokinetic Studies Of Amoxcillin Trihydrate In Healthy Buffalo Calves
260			_c2010
502			_aThe present study was designed to determine and compare the pharmacokinetic parameters of Farmox (Test Product) and Amoxi-vet (Reference Product) in healthy buffalo calves. For this study sixteen healthy buffalo calves between the ages of 6 to 12 months were purchased from the local market. They were kept in the shed of University of Veterinary and Animal Sciences Lahore. Their health status was monitored by physical examination. All the animals were maintained under similar conditions. The calves were provided fodder and water. All the animals were dewormed with Albendazole and a fifteen days wash out period was observed after deworming. The study was cross over design. Calves were divided into two groups A and B having eight animals in each. In the first phase calves of group A were administered Farmox (Test Product) intramuscular at the dose of 15mg/kg body weight and calves of group B were administered Amoxi-vet (Reference Product) intramuscularly at the dose of 15mg/kg body weight. In the second phase of the study, after a washout period of 15 days, group A were administered Amoxi-vet (Reference Product) and group B received the treatment with Farmox at same dose rate. Then 5ml blood was collected by direct pricking of jugular vein with needle and the blood was collected in heparinized test tubes. Prior to drug administration control/blank 5ml blood sample was also collected from each animal. After the drug administration the blood samples were collected at 0.166, 0.33, 0.50, 0.75, 1.0, 1.5, 2.0, 3.0, 4.0, 6.0, 8.0, 12.0, 24.0, 36.0 and 48.0 hours. The blood samples were then centrifuged at 4000 rpm for 10 minutes. Plasma was separated in small capped plastic bottles and measured by high performance liquid chromatographic (HPLC) method. Calculation of all the pharmacokinetic parameters was done by entering plasma concentration-time data in software APO pharmaceutical analysis MW/PHARM version 3.02. Pharmacokinetic parameters of Farmox and Amoxi-vet were compared. Data was analyzed by appropriate statistical methods and it was concluded that there is no significant difference in pharmacokinetic parameters of Farmox (Test Product) and Amoxi-vet (Reference Product) after intramuscular administration and both products are bioequivalent in their rate and extent.
650			_aDepartment of Pharmaoclogy & Toxicology _95037
700			_aProf. Dr. Muhammad Ashraf _95038
942			_cTH
999			_c2920 _d2920