000			02432nam a2200193Ia 4500
005			20151006154114.0
008			150525s2013xx 000 0 und d
041			_aeng
082			_a1788,T
100			_aMuhammad Zeeshan Saleem _98683
110			_cProf. Dr. Muhammad Ashraf _94840
245			_aPharmacokinetic Study Of Different Dosage Forms Of Potassium Iodide (Renessans) In Healthy Human Volunteers
260			_c2013
502			_aThis project was designed to determine the pharmacokinetic parameters of different dosage forms of potassium iodide in healthy human volunteers and also to compare the pharmacokinetic parameters of potassium iodide in healthy male and female volunteers. For this study 36 healthy volunteers were selected (Divided into three groups, 6 male and 6 female in each group). Only those volunteers who were between ages 20-35 were selected, not suffering from any disease. Volunteers were clearly informed about the objectives of study and written consent was taken. Healthy volunteers were divided in to three equal groups and were given capsule, solution, powder dosage form of potassium iodide respectively through oral route. 5ml blood samples were collected at 0, 0.25, 0.5, 1.0, 1.5, 2.0, 2.5, 3.0, 4.0, 6.0, 8.0, 10, 12, and 24 hours from vein of either arm with I/v branula. Plasma was separated by centrifugation at 3000 RPM for 10 minutes and was stored at -80 0C till analysis. Method for the determination of potassium iodide was validated appropriately and analysis of samples was performed on HPLC. All pharmacokinetic parameters were calculated by entering plasma concentration-time data in excel based software PK solutions version 2.0. Pharmacokinetic parameters of potassium iodide in healthy individuals were studied by using statistical tests mean ± SD (standard deviation) and One Way ANOVA. Pharmacokinetic comparison of different dosage forms of potassium iodide in healthy male and female volunteers was studied by unpaired t-test. Results were summarized in tables. Between the dosage forms there is significant difference in the pharmacokinetic parameters of healthy human volunteers but there was no significant difference found in pharmacokinetic parameters between healthy male and female volunteers in each dosage form.
650			_aDepartment of Pharmaoclogy & Toxicology _95037
700			_aDr. Aualeha Riffat _98684
700			_aDr. Mateen _95138
942			_cTH
999			_c3496 _d3496