| 000 -LEADER |
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| fixed length control field |
02466nam a22002057a 4500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20161014090024.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
161014b2016 xxu||||| |||| 00| 0 eng d |
| 041 ## - LANGUAGE CODE |
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| Language code of text/sound track or separate title |
eng |
| 082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER |
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| Classification number |
2566-T |
| 100 ## - MAIN ENTRY--AUTHOR NAME |
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| Personal name |
Jawairia Akram (2010-VA-492) |
| 110 ## - MAIN ENTRY--CORPORATE NAME |
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| Location of meeting |
Dr. Asif Nadeem |
| 245 ## - TITLE STATEMENT |
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| Title |
Sequence Analysis Of Violent Behavior Gene Among Criminals |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) |
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| Year of publication |
2016. |
| 300 ## - PHYSICAL DESCRIPTION |
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| Number of Pages |
69p.; |
| 502 ## - DISSERTATION NOTE |
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| Dissertation note |
Violence is defined as uncontrolled emotions problem and is a reason of violent behavior among criminals. Violence is mostly physical towards other people. MAOA and MAOB are isozymes of monoamine oxidase. MAOA is associated with aggression and violence in criminals as it affects brain structure and function which ultimately causes violence and aggression MAOA gene present on mitochondrial outer membrane encodes monoamine oxidase that degrade neurotransmitters like dopamine, serotonin, epinephrine and nor epinephrine. An SNP (MAOA-LPR) in long promoter region of MAOA alters transcriptional activity of monoamine oxidase A and have two allelic forms MAOA-L and MAOA-H. MAOA-L is low activity allele and MAOA-H is high activity allele. Different research study suggested that MAOA-L is strongly associated with criminal activity in males. Aim of the study was to analyze the sequence of extreme violent behavior gene (MAOA) among criminals. Samples (n= 20) were collected from convicted offenders. Control samples (n=20) were collected from UVAS students. Organic method of DNA extraction was used. BPAQ (Buss and perry aggression questionnaire) was also filled by all the subjects included in the study. Primers for PCR amplification were designed using Primer3 software. PCR products were sequenced bi-directionally on ABI 3130XL Genetic analyzer. Results of sequencing were analyzed using CHROMAS software. Sequence alignment tool like BLAST (Basic local alignment search tool) was used for SNPs identification. 3 intronic and 1 exonic SNPs were observed and confirmed by BLAST. Exonic SNP gave significant p values computed by Chi square calculator. However, intronic SNPs were not significant according to chi square test. SNPs identified were not found to be associated with self-reported aggression. SNP observed in exon 14 is reported to be involved in psychiatric and depressive disorders. |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical Term |
Department of Forensic Science |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Dr. Muhammad Imran |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Dr. Saadat Ali |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Koha item type |
Thesis |
